Will my baby be born healthy ?
Are you anxious about the risk of miscarriage
in prenatal tests?
Are you concerned about the accuracy
of current tests ?
A New Non-Invasive Maternal Blood Test
To Detect Fetal Chromosomal Abnormalities
INEX will be opening our new state-of-the-art Next Generation Sequencing Lab in Singapore in the first quarter of 2015.

What is iGeneScreenTM

Safe. Non-Invasive. 99% Accurate.

iGeneScreenTM is a safe, non invasive, highly accurate prenatal blood test that analyses cell-free fetal DNA in maternal blood to detect fetal trisomies. It involves taking a 10 ml sample of blood from the expectant mother as early as 10 weeks of pregnancy.

iGeneScreenTM has been validated prospectively on 11,105 cases, the largest prospective study for any non-invasive prenatal test to date.

The study showed iGeneScreenTM to be more than 99% accurate in detecting chromosomal abnormalities, in particular Down Syndrome and Edwards Syndrome.

The study was independently peer-reviewed and published in Prenatal Diagnosis, an internationally recognised publication, and the Official Journal of the International Society for Prenatal Diagnosis (ISPD).

iGeneScreenTM detects Trisomy 21 (Down syndrome), Trisomy 18 (Edwards syndrome) and Trisomy 13 (Patau syndrome) with more than 99% accuracy, compared with existing screening tests such as the nuchal translucency and first trimester screening test.

It is anticipated that the test will very significantly reduce the number of invasive diagnostic tests such as Amniocentesis and Chrorionic Villus Sampling, which carry a risk of miscarriage of about 1 in 100.

How Does It work?

iGeneScreenTM is a simple blood test that can be done at your obstetrician’s clinic. The sample is sent for analysis and usually takes 10-14 days to get results. Using a technology called Massively Parallel Sequencing (MPS), scientists analyse cell-free fetal DNA extracted from the maternal blood sample.

iGeneScreenTM is the only test that is more than 99% accurate* for the detection of Down Syndrome and other fetal chromosomal abnormalities.

* As of October 2012, more than 70,000 blood tests have been conducted on women aged 18 to over 40, with more than 99% accuracy.

Am I eligible?

iGeneScreenTM is suitable for pregnant women at 10 weeks gestation and above. Women with associated risks such as increased maternal age, noted to be at ‘high risk’ on other screening tests such as the first trimester screen and/or the following conditions could also choose to perform the test.

  • A family history of an inherited condition
  • A previous pregnancy with a fetal abnormality

BGI Clinical Laboratories is accredited by CNAS (www.cnas.org.cn), which is recognized by The National Association of Testing Authorities, Australia (NATA), by virtue of NATA's Mutual Recognition Agreement (MRA).

iGeneScreenTM is a trademark of INEX, and is conducted by BGI, the world's largest commercial genetic sequencing facility1 with presence in Asia, Europe and the Americas.

1 Source: Bloomberg BusinessWeek "BGI's Young Chinese Scientists Will Map Any Genome"
February 07, 2013

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